Reactive trityl derivatives: stabilised carbocation mass-tags for life sciences applications
نویسندگان
چکیده
منابع مشابه
Reactive trityl derivatives: stabilised carbocation mass-tags for life sciences applications.
The rational design of novel triarylmethyl (trityl)-based mass tags (MT) for mass-spectrometric (MS) applications is described. We propose a "pK(R+) rule" to correlate the stability of trityl carbocations with their MS performance: trityls with higher pK(R+) values ionise and desorb better. Trityl blocks were synthesised that have high pK(R+) values and are stable in conditions of MS analysis; ...
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ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2008
ISSN: 1477-0520,1477-0539
DOI: 10.1039/b810600b